Marine natural products targeting phospholipases A2

Florence Folmer (1, 2) , Marcel Jaspars (2) , Marc Schumacher (1) , Mario Dicato (1) , Marc Diederich (1)

1 LBMCC - Laboratoire de Biologie Moléculaire et Cellulaire du Cancer [Luxembourg]
2 Department of Chemistry

Phospholipases A (PLAs) form a family of enzymes catalyzing the hydrolysis of membrane phospholipids into arachidonic acid, which is the major precursor of pro-inflammatory eicosanoids. As a result, PLAs have been considered as potential targets in anti-inflammatory drug discovery.

Mots clés: anti-inflammatory; arachidonic acid; eicosanoids; marine natural product; membrane phospholipids; PLA

Florence Folmer, Marcel Jaspars, Marc Schumacher, Mario Dicato, Marc Diederich. Marine natural products targeting phospholipases A2. Biochemical Pharmacology, 2010, 80 (12), pp.1793. ⟨10.1016/j.bcp.2010.08.024⟩. ⟨hal-00637158⟩