Rho kinase and hypertension

Angela Wirth (1)

1 Department of Pharmacology [Bad Nauheim]

Arterial hypertension is a multifactorial disease that is characterised by increased peripheral vascular resistance often accompanied by smooth muscle cell hypertrophy and proliferation. Rho kinases (ROCKs) are the most extensively studied effectors of the small G-protein RhoA and abnormalities in RhoA/ROCK signalling have been observed in various cardiovascular disease including hypertension. The RhoA/ROCK-pathway is a key player in different smooth muscle cell functions including contractility, proliferation and migration. Futhermore, there is extensive crosstalk between RhoA/ROCK- and NO-signalling. Therefore, not only ROCK inhibitors but also NO-donators or pleiotropic agents like statins exert their beneficial effects on the cardiovascular system at least in part via Rho/Rho-kinase.

Mots clés: Rho kinase; hypertension; NO-signalling; Rho kinase inhibitors; statins

Angela Wirth. Rho kinase and hypertension. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (12), pp.1276. ⟨10.1016/j.bbadis.2010.05.002⟩. ⟨hal-00636185⟩