Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

Xujun Wu (1, 2) , Matthew D. Jones (2) , Matthew G. Davidson (2) , Julian B. Chaudhuri (2) , Marianne J. Ellis (2)

1 Department of Chemical Engineering, Centre for Regenerative Medicine
2 Department of Chemistry

One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.

Mots clés: PLGA; Scaffold; Tissue engineering; Water droplet templating

Xujun Wu, Matthew D. Jones, Matthew G. Davidson, Julian B. Chaudhuri, Marianne J. Ellis. Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure. Biotechnology Letters, 2010, 33 (2), pp.423-430. ⟨10.1007/s10529-010-0438-y⟩. ⟨hal-00633989⟩