Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia

Jonathan Flint (1) , Iain Mathieson (1) , Marcus Munafò (1)

1 Nuffield Department of Clinical Medicine [Oxford]

Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However to date there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and 3 genome wide association studies containing a total of 11,626 cases and 15,237 controls. We tested 1,241 SNPs in total, and estimated that our power to detect an effect from a variant with minor allele frequency > 5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.

Mots clés: schizoprenia; imputation; meta-analysis; genetic association; DISC1; candidate gene

Jonathan Flint, Iain Mathieson, Marcus Munafò. Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. Molecular Psychiatry, 2011, ⟨10.1038/mp.2011.41⟩. ⟨hal-00631259⟩