Databases in the area of Pharmacogenetics

Sarah C Sim (1) , Russ B Altman (2) , Magnus Ingelman-Sundberg (3)

1 Department of Physiology and Pharmacology
2 Department of Bioengineering
3 Department of Physiology and Pharmacology

In the area of pharmacogenetics and personalized health care it is obvious that databases providing important information of the occurrence and consequences of variant genes encoding drug metabolizing enzymes, drug transporters, drug targets and other proteins of importance for drug response or toxicity, are of critical value for scientists, physicians and industry. The primary outcome of the pharmacogenomic field is the identification of biomarkers that can predict drug toxicity and drug response, thereby individualizing and improving drug treatment of patients. The drug in question and the polymorphic gene exerting the impact are the main issues to be searched for in the databases. Here, we review the databases that provide useful information in this respect, of benefit for the development of the pharmacogenomic field.

Mots clés: Life Sciences

Sarah C Sim, Russ B Altman, Magnus Ingelman-Sundberg. Databases in the area of Pharmacogenetics. Human Mutation, 2011, 32 (5), pp.526. ⟨10.1002/humu.21454⟩. ⟨hal-00629068⟩