Long term azithromycin use in patients with Chronic Obstructive Pulmonary Disease and Tracheostomy

Francesco Blasi , Daniela Bonardi , Stefano Aliberti , Paolo Tarsia , Marco Confalonieri , Omar Amir , Mauro Carone , Fabiano Di Marco , Stefano Centanni , Enrico Guffanti

Patients with Chronic Obstructive Pulmonary Disease (COPD) and tracheostomy are at high risk for exacerbations and hospitalizations. Macrolide treatment has shown to reduce exacerbations in moderate-to-severe COPD. To evaluate the safety and the efficacy of long-term azithromycin use in outpatients with severe COPD and tracheostomy.

Mots clés: macrolide; COPD; acute exacerbation of chronic bronchitis; tracheostomy; quality of life; Maugeri Respiratory Failure questionnaire; C-reactive protein; erythrocyte sedimentation rate; Exhaled Breath Condensate; colony forming units; minimum inhibitory concentrations; Tumor necrosis factor-a; enzyme immunoassay kit; standard care; azithromycin

Francesco Blasi, Daniela Bonardi, Stefano Aliberti, Paolo Tarsia, Marco Confalonieri, et al.. Long term azithromycin use in patients with Chronic Obstructive Pulmonary Disease and Tracheostomy. Pulmonary Pharmacology & Therapeutics, 2010, 23 (3), pp.200. ⟨10.1016/j.pupt.2009.12.002⟩. ⟨hal-00628366⟩