Inhaled Corticosteroid Therapy with Nebulized Beclometasone Dipropionate

Gabriele Nicolini , Giovanni Cremonesi , Andrea S. Melani

Inhaled corticosteroids (ICS) are the most effective anti-inflammatory agents for the management of chronic persistent asthma, and are therefore recommended as first-line antiasthmatic therapy in children and adults. In various settings, the administration of ICS via nebulizer rather than hand-held inhaler (HHI) may have certain advantages, as many patients with HHI fail to use these devices properly or efficiently. In particular, young children, the elderly, the acutely ill, and those with restricted dexterity may be unable to coordinate inhalation with actuation of the device or to generate sufficient inspiratory flow to operate breath-actuated devices effectively. Compliance with nebulized therapy may also be better than that with a pressurized metered-dose inhaler (pMDI) plus spacer.

Mots clés: beclometasone dipropionate; chronic persistent asthma; hand-held inhalers; inhaled corticosteroids; jet nebulizers; nebulization; nebulizer therapy; ultrasonic nebulizers

Gabriele Nicolini, Giovanni Cremonesi, Andrea S. Melani. Inhaled Corticosteroid Therapy with Nebulized Beclometasone Dipropionate. Pulmonary Pharmacology & Therapeutics, 2010, 23 (3), pp.145. ⟨10.1016/j.pupt.2009.11.003⟩. ⟨hal-00628364⟩