Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa.

Didier Hocquet (1) , Barbara Dehecq , Xavier Bertrand (2) , Patrick Plésiat (1)

1 API - Agents pathogènes et inflammation - UFC (EA 4266)
2 LCE - Laboratoire Chrono-environnement (UMR 6249)

The prevalence of class D extended-spectrum oxacillinases (ES-OXAs) in ceftazidime-resistant strains of Pseudomonas aeruginosa is often underestimated by double-disk synergy tests (DDST) using clavulanate. A DDST with a customized distance between a disk of ceftazidime or cefepime and inhibitors (clavulanate and imipenem) detected 14 out of 15 different ES-OXAs.

Domaines: Microbiologie et Parasitologie

Didier Hocquet, Barbara Dehecq, Xavier Bertrand, Patrick Plésiat. Strain-tailored double-disk synergy test detects extended-spectrum oxacillinases in Pseudomonas aeruginosa.. Journal of Clinical Microbiology, 2011, 49 (6), pp.2262-5. ⟨10.1128/JCM.02585-10⟩. ⟨hal-00627176⟩