Comparative study on synteny between yeasts and vertebrates

Guénola Drillon (1) , Fischer Gilles (1)

1 LGM - Génomique des Microorganismes

We computed the regions of conserved synteny between pairwise combinations amongst 13 vertebrate and 18 yeast genomes to perform a combined analysis of the evolution of chromosome maps in yeasts and vertebrates. In vertebrates, the number of conserved synteny blocks exponentially increases along with the protein divergence while concomitantly; the number of genes per block exponentially decreases. In yeasts, the same trends are found but when protein divergence exceeds 36%, the number of blocks gradually decreases. For comparable evolutionary distances, vertebrate genomes are 6 to 8-fold more rearranged than yeast genomes. The rate of rearrangements is 3.1-fold higher in vertebrates than in yeasts, and is estimated to be of 2 rearrangements/Myr. However, when normalized by genome sizes, both the numbers and the rates of rearrangements per Mb are much higher in yeast than in vertebrate genomes.

Mots clés: yeast; vertebrate; synteny; genome; evolution; chromosome; rearrangements

Domaines: Bio-informatique [q-bio.QM]; Bio-Informatique, Biologie Systémique [q-bio.QM]

Guénola Drillon, Fischer Gilles. Comparative study on synteny between yeasts and vertebrates. Comptes Rendus Biologies, 2011, 334 ((8-9)), pp.629-638. ⟨10.1016/j.crvi.2011.05.011⟩. ⟨hal-00626818⟩