Chronic Sclerosing Sialadenitis (Küttner Tumor) As a Member of IgG4-related Diseases: a Clinicopathological Study of 6 Cases From Central Europe

Jan Laco (1) , Ales Ryska (1) , Petr Celakovsky (2) , Helena Dolezalova (3) , Radovan Mottl (1) , Lubos Tucek (1)

1 The Fingerland Department of Pathology
2 Department of Otorhinolaryngology
3 Department of Dentistry

Chronic sclerosing sialadenitis (CSS) has been recently proposed to be member of IgG4-related disease in Japanese and American series. The aim of our study was to validate these results in a cohort of European patients. Our CSS-series includes 4 females and 2 males, aged 32-76 years, all presenting with unilateral swelling of submandibular gland. Microscopically, all CSS-cases showed similar morphology - preservation of lobular architecture accentuated by cellular fibrous bands, dense lymphoplasmacytic inflammation and varied acinar atrophy. Ductal lymphocytes were detected in 3 cases. In 5 cases, the presence of intraductal secretory material accompanied by parenchymal neutrophils was observed. Obliterative phlebitis was seen in 3 cases. The inflammatory infiltrate was composed of T- and B-lymphocytes and polyclonal plasma cells. Median number of IgG-positive plasma cells per 1 HPF was 157; median number of IgG4-positive plasma cells per 1 HPF was 133. Median value of IgG4/IgG ratio was 0.84. Ours is the first European series to prove that CSS belongs to the family of IgG4-related disease. Unlike prior studies, we found in CSS rarely described ductal lymphocytes and parenchymal neutrophils. CSS displays consistent morphology, with increased numbers of IgG4-positive plasma cells and should be regarded as member of IgG4-related disease group.

Mots clés: Medicine

Jan Laco, Ales Ryska, Petr Celakovsky, Helena Dolezalova, Radovan Mottl, et al.. Chronic Sclerosing Sialadenitis (Küttner Tumor) As a Member of IgG4-related Diseases: a Clinicopathological Study of 6 Cases From Central Europe. Histopathology, 2011, 58 (7), pp.1157. ⟨10.1111/j.1365-2559.2011.03833.x⟩. ⟨hal-00626288⟩