Oxidized low density lipoprotein inhibits phosphate signaling and phosphate-induced mineralization in osteoblasts. Involvement of oxidative stress

Cécile Mazière (1, 2) , Valéry Savitsky (2, 1) , Antoine Galmiche (2, 1) , Cathy Gomila (2, 1) , Ziad Massy (1) , Jean-Claude Mazière (2, 1)

1 MECANISMES PHYSIOPATHOLOGIQUES ET CONSEQUENSES DES CALCIFICATIONS CARDIOVASCULAIRES
2 North Hospital

It is well admitted that oxidized LDL (OxLDL) plays a major role in the generation and progression of atherosclerosis. Since atherosclerosis is often accompanied by osteoporosis, the effects of OxLDL on phosphate-induced osteoblast mineralization were investigated.

Mots clés: Pi; OxLDL; OPN; RANKL; ERK; JNK; AP1; CREB; Osteoblasts; differentiation; oxidative stress; signaling

Cécile Mazière, Valéry Savitsky, Antoine Galmiche, Cathy Gomila, Ziad Massy, et al.. Oxidized low density lipoprotein inhibits phosphate signaling and phosphate-induced mineralization in osteoblasts. Involvement of oxidative stress. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (11), pp.1013. ⟨10.1016/j.bbadis.2010.07.010⟩. ⟨hal-00623294⟩