EEG source analysis in obsessive-compulsive disorder

Jana Kopřivová (1) , Marco Congedo (2) , Jiří Horáček (1) , Ján Praško (1) , Michal Raszka (1) , Martin Brunovský (1) , Barbora Kohútová (1) , Cyril Höschl (1)

1 3. LF UK / 3rd Faculty of Medicine - 3. lékařská fakulta, Univerzita Karlova [Praha, Česká republika] = Third Faculty of Medicine, Charles University [Prague, Czech Republic]
2 GIPSA-VIBS - GIPSA - Vision and Brain Signal Processing

OBJECTIVE: The goal of this study was to assess the activity of intracortical EEG sources in patients with OCD. METHODS: We compared resting state EEG from 50 OCD patients and 50 matched controls using standardized low-resolution electromagnetic tomography (sLORETA) and normative independent component analysis (NICA). Data were analyzed with 1 Hz frequency resolution. Group ICA was used to separate 7 independent components from the control group data. The resulting weights and norms served to derive the same components from the OCD group and to compare their power with controls. RESULTS: In OCD, sLORETA indicated low-frequency power excess (2 - 6 Hz) in the medial frontal cortex, whereas group ICA showed increased low-frequency power in a component reflecting the activity of subgenual anterior cingulate, adjacent limbic structures and to a lesser extent also of lateral frontal cortex. CONCLUSIONS: Both methods provided evidence for medial frontal hyperactivation in OCD. SIGNIFICANCE: Our study is the first to use normative ICA in a clinical sample and indicates its potential utility as a diagnostic tool. The findings provide consistent results based on EEG source localization in OCD and are of practical interest for therapeutic interventions.

Mots clés: obsessive-compulsive disorder (OCD); standardized low-resolution electromagnetic tomography (sLORETA); independent component analysis (ICA); medial frontal cortex

Domaines: Neurosciences

Jana Kopřivová, Marco Congedo, Jiří Horáček, Ján Praško, Michal Raszka, et al.. EEG source analysis in obsessive-compulsive disorder. Clinical Neurophysiology, 2011, 122 (9), pp.1735-1743. ⟨10.1016/j.clinph.2011.01.051⟩. ⟨hal-00620687⟩