HAL : hal-00618366, version 1

PubMed : 1669292

DOI : 10.1002/hipo.450010206

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Hippocampus 1, 2 (1991) 181-92

Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.

T. Otto 1, H. Eichenbaum, Sidney I. Wiener 2, C. G. Wible

(04/1991)

Recent studies have revealed 3 stimulation parameters that together comprise the temporal pattern of neuronal activation optimal for the induction of hippocampal LTP: high-frequency bursts, activity 100-200 ms prior to a burst, and burst delivery in phase with the ongoing hippocampal theta rhythm. The present paper reports that these 3 aspects of patterned neural activity, collectively referred to as "theta-bursting," are characteristic of the spike trains of CA1 pyramidal cells in rats during the sampling and analysis of learning cues in an odor discrimination task and during performances of a spatial memory task. In contrast, theta-bursting occurs relatively infrequently during behavioral events less directly related to task-relevant mnemonic processing. These findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time-locked to behavioral events critical to learning.

1 :	Laboratoire Ecologie Fonctionnelle et Environnement (EcoLab)
	PRES Université de Toulouse – Institut National Polytechnique de Toulouse - INPT – Université Paul Sabatier [UPS] - Toulouse III – Observatoire Midi-Pyrénées – CNRS : UMR5245
2 :	Laboratoire de Physiologie de la Perception et de l'Action (LPPA)
	CNRS : UMR7152 – Collège de France

Domaine

:

Sciences cognitives/Neurosciences

hal-00618366, version 1

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Contributeur : Sidney I Wiener <>

Soumis le : Jeudi 1 Septembre 2011, 15:10:01

Dernière modification le : Jeudi 1 Septembre 2011, 15:10:01