The mitochondrial citrate carrier: a new player in inflammation

Vittoria Infantino , Paolo Convertini , Liana Cucci , Maria Antonietta Panaro , Maria Antonietta Di Noia , Rosa Calvello , Ferdinando Palmieri , Vito Lacobazzi (1)

1 Pharmaco-Biology Department, laboratory of Biochemistry and Molecular Biology

The citrate carrier (CIC) catalyzes the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. Herein we show that CIC mRNA and protein markedly increase in LPS-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of nitric oxide, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

Mots clés: Life Sciences

Vittoria Infantino, Paolo Convertini, Liana Cucci, Maria Antonietta Panaro, Maria Antonietta Di Noia, et al.. The mitochondrial citrate carrier: a new player in inflammation. Biochemical Journal, 2011, 438 (3), pp.433-436. ⟨10.1042/BJ20111275⟩. ⟨hal-00617325⟩