Inflammation in Transgenic Mouse Models of Neurodegenerative Disorders

Claudia Schwab (1) , Andis Klegeris (2) , Patrick L. Mcgeer (1)

1 Department of Psychiatry
2 Department of Biology

Much evidence is available that inflammation contributes to the development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Our review investigates how well current mouse models reflect this aspect of the pathogenesis.

Mots clés: Transgenic mice; Alzheimer's disease; Parkinson's disease; Huntington's disease; immune system; microglia; cytokines; complement system

Claudia Schwab, Andis Klegeris, Patrick L. Mcgeer. Inflammation in Transgenic Mouse Models of Neurodegenerative Disorders. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (10), pp.889. ⟨10.1016/j.bbadis.2009.10.013⟩. ⟨hal-00616908⟩