Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance

Murugan Kalimutho (1) , Antonella Minutolo (2, 3) , Sandro Grelli (2, 3) , Amanda Formosa (1) , Giulia Sancesario (1) , Alessandra Valentini (1) , Giorgio Federici (1) , Sergio Bernardini (1)

1 Department of Internal Medicine
2 Department of Experimental Medicine and Biochemical Sciences
3 Department of Laboratory Medicine, "U.O.C. Clinical Microbiology"

Mots clés: Satraplatin; CRC; Apoptosis; Platinum; p53; Oxaliplatin; miR-34a

Murugan Kalimutho, Antonella Minutolo, Sandro Grelli, Amanda Formosa, Giulia Sancesario, et al.. Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance. Cancer Chemotherapy and Pharmacology, 2010, 67 (6), pp.1299-1312. ⟨10.1007/s00280-010-1428-4⟩. ⟨hal-00616701⟩