Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)
Daniele Campa
(1)
,
Rainer Claus
(1)
,
Lucie Dostal
(1)
,
Angelika Stein
(1)
,
Jenny Chang-Claude
(1)
,
Karina Meidtner
(2)
,
Heiner Boeing
(2)
,
Anja Olsen
(3)
,
Anne Tjønneland
(3)
,
Kim Overvad
(4, 5)
,
Laudina Rodríguez
(6)
,
Catalina Bonet
(7)
,
Maria-José Sánchez
(8, 9)
,
Pilar Amiano
(9, 10)
,
José María Huerta
(9, 11)
,
Aurelio Barricarte
(9, 12)
,
Kay-Tee Khaw
(13)
,
Nicholas J. Wareham
(14)
,
Ruth C. Travis
(15)
,
Naomi E. Allen
(15)
,
Antonia Trichopoulou
(16, 17)
,
Christina Bamia
(17)
,
Vassiliki Benetou
(17)
,
Domenico Palli
(18)
,
Claudia Agnoli
(19)
,
Salvatore Panico
(20)
,
Rosario Tumino
(21)
,
Carlotta Sacerdote
(22, 23)
,
Henk Kranen
(24)
,
H. Bas Bueno-De-Mesquita
(24)
,
Petra H. M. Peeters
(25)
,
Carla H. Gils
(25)
,
Per Lenner
(26)
,
Malin Sund
(27)
,
Eiliv Lund
(28)
,
Inger Torhild Gram
(28)
,
Sabina Rinaldi
(29)
,
Veronique Chajes
(29)
,
Isabelle Romieu
(29)
,
Pierre Engel
(30)
,
Marie Christine Boutron-Ruault
(30)
,
Françoise Clavel-Chapelon
(30)
,
Afshan Siddiq
(31)
,
Elio Riboli
(31)
,
Federico Canzian
(1)
,
Rudolf Kaaks
(1)
1
Department of Cancer Epidemiology
2 Department of Epidemiology
3 Institute of Cancer Epidemiology
4 Department of Cardiology, Center for Cardiovascular Research
5 Department of Epidemiology, School of Public Health
6 Public Health and Participation Directorate
7 Department of Epidemiology
8 Andalusian School of Public Health [Granada]
9 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
10 Public Health Division of Gipuzkoa
11 Department of Epidemiology
12 Navarre Public Health Institute
13 University of Cambridge School of Clinical Medicine
14 MRC Epidemiology Unit
15 Nuffield Department of Clinical Medicine [Oxford]
16 Hellenic Health Foundation
17 WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene
18 Molecular and Nutritional Epidemiology Unit
19 IRCCS Istituto Nazionale dei Tumori [Milano]
20 Department of Clinical and Experimental Medicine
21 Cancer registry and Histopathology Unit
22 CPO Piemonte - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in Piemonte = Center for Cancer Prevention-Piemonte
23 Human Genetic Foundation (HuGeF)
24 Centre for Nutrition and Health (CVG)
25 Julius Center
26 Department of Public Health and Clinical Medicine
27 Department of Surgery
28 Institute of Community Medicine University of Tromsø
29 IACR - International Agency for Cancer Research
30 CESP - Centre de recherche en épidémiologie et santé des populations
31 Imperial College London
2 Department of Epidemiology
3 Institute of Cancer Epidemiology
4 Department of Cardiology, Center for Cardiovascular Research
5 Department of Epidemiology, School of Public Health
6 Public Health and Participation Directorate
7 Department of Epidemiology
8 Andalusian School of Public Health [Granada]
9 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
10 Public Health Division of Gipuzkoa
11 Department of Epidemiology
12 Navarre Public Health Institute
13 University of Cambridge School of Clinical Medicine
14 MRC Epidemiology Unit
15 Nuffield Department of Clinical Medicine [Oxford]
16 Hellenic Health Foundation
17 WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene
18 Molecular and Nutritional Epidemiology Unit
19 IRCCS Istituto Nazionale dei Tumori [Milano]
20 Department of Clinical and Experimental Medicine
21 Cancer registry and Histopathology Unit
22 CPO Piemonte - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in Piemonte = Center for Cancer Prevention-Piemonte
23 Human Genetic Foundation (HuGeF)
24 Centre for Nutrition and Health (CVG)
25 Julius Center
26 Department of Public Health and Clinical Medicine
27 Department of Surgery
28 Institute of Community Medicine University of Tromsø
29 IACR - International Agency for Cancer Research
30 CESP - Centre de recherche en épidémiologie et santé des populations
31 Imperial College London
Anja Olsen
- Fonction : Auteur
- PersonId : 757529
- ORCID : 0000-0003-4788-503X
Anne Tjønneland
- Fonction : Auteur
- PersonId : 757260
- ORCID : 0000-0003-4385-2097
Claudia Agnoli
- Fonction : Auteur
- PersonId : 764700
- ORCID : 0000-0003-4472-1179
Salvatore Panico
- Fonction : Auteur
- PersonId : 757530
- ORCID : 0000-0002-5498-8312
Rosario Tumino
- Fonction : Auteur
- PersonId : 757261
- ORCID : 0000-0003-2666-414X
Elio Riboli
- Fonction : Auteur
- PersonId : 757264
- ORCID : 0000-0001-6795-6080
- IdRef : 030854032
Federico Canzian
- Fonction : Auteur
- PersonId : 763126
- ORCID : 0000-0002-4261-4583
- IdRef : 18925243X
Rudolf Kaaks
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- Fonction : Auteur correspondant
- PersonId : 882399
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Résumé
AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (, , and ). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing.
Origine : Fichiers produits par l'(les) auteur(s)
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