Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals

D Tousoulis (1) , Nikolaos Papageorgiou (1) , Theodora Psaltopoulou (1) , Anastasios Giolis (1) , Charalambos Antoniades (1) , Eleftherios Tsiamis (1) , Antigoni Miliou (1) , Kostas Toutouzas (1) , Gerasimos Siasos (1) , Christodoulos Stefanadis (1)

1 1st Cardiology Department, Hippokration Hospital

Objective: Inter-cellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and tumor necrosis factor alpha (TNF-a), are implicated in atherogenesis. Additionally, several types of oil as part of different types of diet are associated with the initiation of atherosclerosis and consequently with the risk of cardiovascular disease. However, the exact role of oil consumption on vascular inflammation remains unknown. In the present parallel study, we assessed the acute effects of extra virgin olive oil, soy oil, corn oil and cod liver oil on circulating soluble (s) forms of adhesion molecules and TNF-a. Methods: Sixty seven healthy volunteers were randomized to receive 50 ml of oil. Soluble forms of VCAM-1, ICAM-1 and TNF-a were measured by enzyme-linked immunosorbent assay (ELISA) at baseline and 3 hours post oil consumption. Results: All types of oil had no significant effect on sVCAM-1 levels (p=NS for all). On the contrary, all oil types decreased ICAM-1 levels (p<0.01). Olive oil (p<0.05), soy oil and cod liver oil (p<0.01 for both) reduced TNF-a levels significantly, in contrast to corn oil, which induced a non-significant decrease (p=NS). Moreover, there was a significant correlation between the absolute change in ICAM-1 and TNF-a levels (rho=0.379, p<0.05), but not between the absolute changes in VCAM-1 and TNF-a levels (rho=0.019, p=NS). Conclusions: Acute consumption of all types of oil decreased significantly ICAM-1 levels. In addition, olive oil, soy oil and cod liver oil decreased significantly TNF-a levels. Moreover, the absolute change in TNF-a levels was correlated with the absolute change in ICAM-1 levels. These findings indicate that acute consumption of specific types of oil is associated with specific significant anti-inflammatory effects.

Mots clés: oil; ICAM-1; VCAM-1; TNF-a; inflammation

D Tousoulis, Nikolaos Papageorgiou, Theodora Psaltopoulou, Anastasios Giolis, Charalambos Antoniades, et al.. Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals. European Journal of Clinical Nutrition, 2011, ⟨10.1038/ejcn.2011.8⟩. ⟨hal-00614740⟩