Effects of glucocorticoids on the neutrophil count: A cohort study among hospitalized patients

Karin J. Velthove , Hubert G.M. Leufkens , Patrick C. Souverein , René C. Schweizer , Madelon Bracke , Wouter W. van Solinge

Systemic glucocorticoids are often used in clinical practice for a large variety of indications. Clinical observations have shown that patients using glucocorticoids often have higher neutrophil counts. Debate remains whether this observed neutrophilia is associated with glucocorticoid use or that other factors, like disease and severity of disease, should be considered. The objective of this study was to investigate the effect of systemic glucocorticoids on the absolute neutrophil count in hospitalized patients.

Mots clés: cohort studies; glucocorticoid; immunology; neutrophil; DTA; GC; UPOD

Karin J. Velthove, Hubert G.M. Leufkens, Patrick C. Souverein, René C. Schweizer, Madelon Bracke, et al.. Effects of glucocorticoids on the neutrophil count: A cohort study among hospitalized patients. Pulmonary Pharmacology & Therapeutics, 2010, 23 (2), pp.129. ⟨10.1016/j.pupt.2009.10.006⟩. ⟨hal-00614330⟩