Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications

Eugenia García-Fernández , Juan Ignacio de Diego , Elena Collantes , Marta Mendiola , María Pilar Prim , Elia Pérez-Fernández , María Miguel-Martín , Manuel Nistal , David Hardisson (1)

1 Department of Pathology

Aims: To investigate the clinical and prognostic significance of Aurora B in laryngeal squamous cell carcinomas (LSCC). Methods and results: Aurora B protein expression was analyzed in a series of 259 LSCC. In addition, the expression of the proliferation index (Ki67) and other proteins involved in cell cycle control, such as Aurora A, survivin and p53 was also determined. Aurora B was highly expressed in 55.4% of LSCC. High Aurora B expression levels were correlated with tumour recurrence (P = 0.01), dead of disease (P = 0.05), and decreased disease-free survival (P = 0.013) and overall survival (P = 0.04). Survivin expression was neither associated with clinicopathological characteristics nor with survival. However, survivin expression in the nucleus paralleled Aurora B expression (P = 0.014). Aurora A expression was significantly associated with increased tumour grade (P = 0.008). Multivariate analysis indicated that Aurora B was an independent predictor for LSCC-specific disease-free survival (hazard ratio [HR], 2.10; 95% confidence interval [95% CI], 1.25-3.52 [P = 0.005]) and overall survival (HR, 1.91; 95% CI, 1.01-3.34 [P = 0.023]). Conclusions: Aurora B may be a novel prognostic biomarker for LSCC and a potential therapeutic target in this type of tumour.

Mots clés: Medicine

Eugenia García-Fernández, Juan Ignacio de Diego, Elena Collantes, Marta Mendiola, María Pilar Prim, et al.. Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications. Histopathology, 2011, 58 (3), pp.368. ⟨10.1111/j.1365-2559.2011.03757.x⟩. ⟨hal-00613878⟩