MOLECULAR CYTOGENETICS OF LYMPHOMA. WHERE DO WE STAND IN 2010?

Philip M Kluin (1) , Ed Schuuring (2)

1 Pathology and Medical Biology
2 Pathology and Medical Biology

Since approximately 20 years most malignant lymphomas are classified by the recognition of clinico-pathologic entities, each with its own combination of clinical, morphologic, immunophenotypic and molecular genetic characteristics. Obviously, in many instances molecular cytogenetics is of great help for classification and in some lymphomas it is even a prerequisite. Molecular cytogenetic alterations can be detected by a large variety of techniques, ranging from conventional cytogenetics to single nucleotide polymorphism analysis. In this review the application with advantages and disadvantage of individual techniques in lymphoma diagnostics is discussed. Secondly, the most recurrent alterations in individual lymphomas are listed. Finally, the authors briefly discuss possible novel developments in this field of lymphoma diagnostics.

Mots clés: Medicine

Philip M Kluin, Ed Schuuring. MOLECULAR CYTOGENETICS OF LYMPHOMA. WHERE DO WE STAND IN 2010?. Histopathology, 2011, 58 (1), pp.128. ⟨10.1111/j.1365-2559.2010.03700.x⟩. ⟨hal-00610743⟩