No pol mutation is associated independently with the lack of immune recovery in patients infected with HIV and failing antiretroviral therapy - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Medical Virology Année : 2011

No pol mutation is associated independently with the lack of immune recovery in patients infected with HIV and failing antiretroviral therapy

Laura Galli
  • Fonction : Auteur
  • PersonId : 906158
Maurizio Zazzi
  • Fonction : Auteur
  • PersonId : 900187
Valeria Ghisetti
  • Fonction : Auteur
  • PersonId : 906159
Stefano Bonora
  • Fonction : Auteur
  • PersonId : 900194
Valeria Micheli
  • Fonction : Auteur
  • PersonId : 906160
Paola Meraviglia
  • Fonction : Auteur
  • PersonId : 906161
Paola Corsi
  • Fonction : Auteur
  • PersonId : 906162
Bianca Bruzzone
  • Fonction : Auteur
  • PersonId : 906163
Stefano Menzo
  • Fonction : Auteur
  • PersonId : 906164
Simona Di Giambenedetto
  • Fonction : Auteur
  • PersonId : 900191
Gaetano Filice
  • Fonction : Auteur
  • PersonId : 906165
Giovanni Penco
  • Fonction : Auteur
  • PersonId : 906166
Antonella Castagna
  • Fonction : Auteur
  • PersonId : 906167

Résumé

We aimed at investigating whether specific pol mutations hinder long-term immune recovery regardless of virological response. In total, 826 patients with >50 HIV RNA copies/mL, who underwent genotypic resistance testing between 1 January 2000 and 31 December 2003 after >3 years of antiretroviral treatment, and were followed up for >3 years after genotypic resistance testing, were analyzed retrospectively. The outcome of the study was the lack of immune recovery after >3 years of follow-up, defined as a slope by linear regression <0. The viremia detectability ratio was defined as the number of HIV RNA values of >50 copies/mL divided by the number of HIV RNA measurements during follow-up. Logistic regression was used for univariable and multivariable analysis. Median (Q1, Q3) values at baseline were the following: age 40 (37, 45) years, years on antiretroviral therapy 4.45 (3.65, 5.47), HIV RNA 3.91 (3.39, 4.53) log10 copies/mL, CD4+ T-cell 358 (211, 524)/µL. After 3.13 years of follow-up, 375 patients (45.4%) showed a lack of immune recovery. The risk of lack of immune recovery increased independently with increasing baseline CD4+ counts (OR = 1.104 per 50-cell increase, 95% CI = 1.069-1.142, p < 0.0001), increasing viremia detectability ratio during follow-up (OR = 1.145 per 0.1-unit increase, 95% CI = 1.093-1.202, p < 0.0001), and with earlier calendar years of resistance testing (overall effect: p = 0.0007). In conclusion, no pol mutation is associated independently with the lack of immune recovery.

Mots clés

Fichier principal
Vignette du fichier
PEER_stage2_10.1002%2Fjmv.21989.pdf (520.54 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00610729 , version 1 (24-07-2011)

Identifiants

Citer

Nicola Gianotti, Laura Galli, Maurizio Zazzi, Valeria Ghisetti, Stefano Bonora, et al.. No pol mutation is associated independently with the lack of immune recovery in patients infected with HIV and failing antiretroviral therapy. Journal of Medical Virology, 2011, 83 (3), pp.391. ⟨10.1002/jmv.21989⟩. ⟨hal-00610729⟩

Collections

PEER
62 Consultations
213 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More