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Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2010

Enhancement of the antibacterial properties of silver nanoparticles using β-cyclodextrin as a capping agent

Résumé

Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH followed by capping with varying concentrations of β-cyclodextrin (β-CD) and were physically characterised. Antibacterial activity against , and was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7nm) than their uncapped equivalents (17nm). Capped particles demonstrated superior photostability when exposed to intense ultraviolet radiation for 4h as well as significantly (<0.05) higher (up to 3.5-fold) antibacterial activity. The influence of β-CD concentration was seen to delay bacterial growth, indicating that a Trojan horse mechanism may be occurring owing to bacterial carbohydrate affinity, thereby enhancing silver ion absorption.
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Dates et versions

hal-00608990 , version 1 (17-07-2011)

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Swarna Jaiswal, Brendan Duffy, Amit Kumar, Niall Stobie, Patrick Mchale. Enhancement of the antibacterial properties of silver nanoparticles using β-cyclodextrin as a capping agent. International Journal of Antimicrobial Agents, 2010, 36 (3), pp.280. ⟨10.1016/j.ijantimicag.2010.05.006⟩. ⟨hal-00608990⟩

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