Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted therapies. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Clinical Practice Année : 2011

Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted therapies.

Paul J Ross
  • Fonction : Auteur correspondant
  • PersonId : 905670

Connectez-vous pour contacter l'auteur
Rosemary Lord
  • Fonction : Auteur
  • PersonId : 905671
Abid Suddle
  • Fonction : Auteur
  • PersonId : 905672

Résumé

Abstract Hepatocellular cancer (HCC) is the fifth most common cause of cancer worldwide and its incidence is increasing due to the dissemination of hepatitis B and C virus infection. Surgical resection and liver transplantation are considered the only cures for HCC, but benefit approximately 10-15% of patients. In addition, radiofrequency ablation may is potentially curative for patients' with small HCC. Some patients with irresectable disease confined to the liver may benefit from embolisation or chemoembolisation. In the presence of disease not amenable to loco-regional therapy median survival is only a few months. Current systemic therapy with cytotoxic chemotherapy induces relatively few responses and has no clear survival benefit. Current interest is focussed on the potential role of targeted therapies based on the key aspects of molecular pathogenesis of HCC, most notably sorafenib, an oral multikinase inhibitor. Recent developments discussed in this article demonstrate the potential benefits of this drug which seems destined to become first-line therapy for advanced HCC.

Mots clés

Fichier principal
Vignette du fichier
PEER_stage2_10.1111%2Fj.1742-1241.2010.02545.x.pdf (245.94 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00608948 , version 1 (16-07-2011)

Identifiants

Citer

Paul J Ross, Rosemary Lord, Abid Suddle. Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted therapies.. International Journal of Clinical Practice, 2011, 65 (2), pp.182. ⟨10.1111/j.1742-1241.2010.02545.x⟩. ⟨hal-00608948⟩

Collections

PEER
24 Consultations
114 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More