Study on the toxicity of inhaled alumina nanoparticles: impact of physicochemical properties and adsorption artifacts on the measurement of biological responses

Mélanie Pailleux (1, 2, 3, 4) , Jérémie Pourchez (4, 5, 6, 7) , Delphine Boudard (7, 8) , Philippe Grosseau (1, 2, 3) , Michèle Cottier (7, 8)

1 LPMG-EMSE - Laboratoire des Procédés en Milieux Granulaires
2 SPIN-ENSMSE - Centre Sciences des Processus Industriels et Naturels
3 P2MC-ENSMSE - Département Poudres et Matériaux Multi-Composants
4 LINA-ENSME - Laboratoire Interdisciplinaire des Nanoparticules Aérosolisées
5 IFRESIS - Institut Fédératif de Recherche en Sciences et Ingénierie de la Santé
6 CIS-ENSMSE - Centre Ingénierie et Santé
7 LINA-ENSMSE - Laboratoire Interdisciplinaire d'Etude des Nanoparticules Aérosolisées
8 Service d'Histologie Embryologie

This work aims at developping a multidisciplinary approach to highlight the correlation between the toxicity of alumina engineered nanoparticles (NP) and their physicochemical characteristics. Accuracy of measurements depends on cell production after contact with particles, but also depends on the ability of biomolecules to get adsorbed on the NP [1]. That's why, mechanisms of biomolecules adsorption on NP must be fully understood to avoid misinterpretation of data.

Mots clés: Toxicity; inhalation; ultrafine alumina nanoparticles; lung; laser particles size analyser; specific surface area technique; BET method; Photon Correlation Spectroscopy

Domaines: Génie des procédés; Toxicologie

Mélanie Pailleux, Jérémie Pourchez, Delphine Boudard, Philippe Grosseau, Michèle Cottier. Study on the toxicity of inhaled alumina nanoparticles: impact of physicochemical properties and adsorption artifacts on the measurement of biological responses. International Conference on Safe Production and Use of Nanomaterials, Nanosafe 2010, Nov 2010, Grenoble, France. pp.012041, ⟨10.1088/1742-6596/304/1/012041⟩. ⟨hal-00607318⟩