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Article Dans Une Revue Biophysical Chemistry Année : 2009

Protein adsorption and desorption on lipid bilayers

Vladimir P. Zhdanov
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Bengt Kasemo
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Résumé

The protein surface usually exhibits one or a few charged spots. If a lipid bilayer contains a significant amount of lipids with oppositely charged head groups, protein adsorption on a bilayer may be energetically favourable due to the protein-lipid electrostatic interaction. The specifics of this case is that the lipids are highly mobile and the protein adsorption is accompanied by the redistribution of lipids between the areas covered and not covered by protein. We present a kinetic model illustrating that this effect is especially interesting if the fraction of the surface covered by charged lipids is relatively low. In this situation, with increasing protein coverage, the protein desorption rate constant rapidly increases while the adsorption rate constant drops, so that there is critical fraction of the area covered by protein. Adsorption above this fraction is hindered both kinetically and thermodynamically.
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Dates et versions

hal-00605248 , version 1 (01-07-2011)

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Vladimir P. Zhdanov, Bengt Kasemo. Protein adsorption and desorption on lipid bilayers. Biophysical Chemistry, 2009, 146 (2-3), pp.60. ⟨10.1016/j.bpc.2009.10.005⟩. ⟨hal-00605248⟩

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