Vitamin D deficiency in Spain: a population-based cohort study
Résumé
ABSTRACT Background: Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been done in Spain involving a large number of participants. Objective: To study the population concentrations of vitamin D in a representative sample of the Spanish population. Subjects/Methods: The study involved two cohorts from Spain. The Asturias Study and the Pizarra Study are two prospective, population-based studies with 2260 participants. In 1262 subjects(age:20-83 years) we studied 25-hydroxyvitamin D, intact parathyroid hormone (PTHi), calcium, phosphorus and creatinine. Results: The median population values of 25-hydroxyvitamin D and PTHi were 22.46 ng/mL and 42.29 pg/mL, respectively. The values of 25-hydroxyvitamin D were significantly higher in summer and correlated with age (beta=-0.050.01, p<0.0001), creatinine (beta=6.421.17, p<0.0001), and PTHi (-0.070.01, p<0.0001), but not with calcium, phosphorus or sex. The increase in PTHi with age was seen whatever the values of 25-hydroxyvitamin D, and was greater in the older persons. The concentration of PTHi rose continuously with effect from 25-hydroxyvitamin D values below 30 ng/mL. Values above 35 ng/mL were associated with a significantly lower concentration of PTHi. Conclusions: One third (33.9%) of the Spanish population may be at risk for Vitamin D deficiency. 25-hydroxyvitamin D values above 30 ng/mL can safely discard "hyper PTH". The increase in PTHi concentration is greater in older persons for similar values of 25-hydroxyvitamin D.
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