polymorphisms, occupational and environmental exposures and risk of bladder cancer

Sofia Pavanello (1) , Giuseppe Mastrangelo (1) , Donatella Placidi (2) , Marcello Campagna (2) , Alessandra Pulliero (1) , Angela Carta (2) , Cecilia Arici (2) , Stefano Porru (2)

1 Occupational Health Section, Department of Environmental Medicine and Public Health
2 Department of Experimental and Applied Medicine, Section of Occupational Medicine and Industrial Hygiene

Cytochrome P4501A2 (CYP1A2) is a key enzyme for activation of bladder carcinogens. Polymorphisms in the 5′-noncoding promoter region of gene [mainly −(rs35694136) and −(rs762551)], are crucial in modifying CYP1A2 activity in smokers. Within the framework of a hospital-based case/control study, we investigated the relationship between polymorphisms, occupational/environmental exposures and bladder cancer (BC) risk. The study population included 185 BC cases and 180 non-cancer controls, all Caucasian males. Data were collected on lifetime smoking, coffee drinking, dietary habits and lifetime occupation, with particular reference to exposure to aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs). A case-only design was applied to study the interaction between − (or −) and occupational and environmental factors. Multiple logistic regression showed a significantly increased risk among heavy smokers (≥50 packyears; OR 5.6, 95% CI: 2.5-12.5) and heavy coffee drinkers (>5 cups/day; OR 3.1, 95% CI: 1.2-7.9). Exposure to AAs showed a significant trend of BC risk with increasing cumulative exposure (CE) ( = 0.04), with heavy smoking as possible confounder A decreased risk was noted for large leaf vegetable consumption, with significant trend from <1/month to >3 times/week ( = 0.008). The case-only analysis showed an interaction between − and tobacco smoking >25 packyears ( = 0.04); no interaction was detected between such polymorphisms and coffee consumption, dietary habits and occupational exposure to AAs. No effects were shown with − genotype as well as no overall effect of by itself on BC risk. This is the first study suggesting that modifies the effect of cigarette smoking on BC risk.

Mots clés: Bladder cancer; genotype; Occupational/environmental exposures

Sofia Pavanello, Giuseppe Mastrangelo, Donatella Placidi, Marcello Campagna, Alessandra Pulliero, et al.. polymorphisms, occupational and environmental exposures and risk of bladder cancer. European Journal of Epidemiology, 2010, 25 (7), pp.491-500. ⟨10.1007/s10654-010-9479-8⟩. ⟨hal-00601523⟩