bacteremia and in a patient with X-linked agammaglobulinemia

T. Bruele (1) , P. E. C. Mourad-Baars (1) , E. C. J. Claas (2) , R. N. Plas (1) , E. J. Kuijper (2) , R. G. M. Bredius (1)

1 Department of Pediatrics
2 Department of Medical Microbiology

We describe a 15-year-old patient with X-linked agammaglobulinemia who developed malabsorption and bacteremia due to infection of and . The bacteremia was only recognized after subculturing of blood culture bottles that failed to signal in the automated system. After 2 weeks of treatment with meropenem and erythromycin for 4 weeks, the patient developed a relapse of bacteremia 10 months later with a high level erythromycin resistant . Sequencing revealed an A2058C mutation in the 23 S rRNA gene associated with this resistance. Treatment with doxycycline for 4 weeks finally resulted in complete eradication. This case report illustrates the importance for physicians to use adapted culture methods and adequate prolonged therapy in patients with an immunodeficiency. A summary of published case reports and series of patients with hypogammaglobulinemia or agammaglobulinemia with or bacteremia is given.

Mots clés: Life Sciences

T. Bruele, P. E. C. Mourad-Baars, E. C. J. Claas, R. N. Plas, E. J. Kuijper, et al.. bacteremia and in a patient with X-linked agammaglobulinemia. European Journal of Clinical Microbiology and Infectious Diseases, 2010, 29 (11), pp.1315-1319. ⟨10.1007/s10096-010-0999-7⟩. ⟨hal-00601188⟩