Tyrosine phosphatase inhibition triggers sustained canonical Serine-dependent NFκB activation via Src-dependent blockade of PP2A

Sandra Barisic , Claudia Schmidt , Henning Walczak , Dagmar Kulms

Activation status of Tyr-kinase Src as well as of the transcription factor NFκB is a decisive criterion for the onset of cancer and in conveying radio-resistance. While the activation status of Src is Tyr-phosphorylation dependent, NFκB activation requires Ser phosphorylation of its cytosolic inhibitor, IκBα⋅ Since constitutive NFκB activation was linked to tumor maintenance, its tight regulation is mandatory.

Mots clés: IKKβ/IκBα/NFκB/PP2A/Src-kinase/Interleukin-1

Sandra Barisic, Claudia Schmidt, Henning Walczak, Dagmar Kulms. Tyrosine phosphatase inhibition triggers sustained canonical Serine-dependent NFκB activation via Src-dependent blockade of PP2A. Biochemical Pharmacology, 2010, 80 (4), pp.439. ⟨10.1016/j.bcp.2010.04.028⟩. ⟨hal-00601169⟩