Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures.

Sinead Ryan (1) , Denise O'Gorman (2) , Yvonne Nolan (3)

1 Anatomy and Neuroscience
2 Marigot Limited
3 Anatomy and Neuroscience

It is well established that neuroinflammation contributes to brain aging, and that cortical cells are particularly vulnerable. Lipopolysaccharide stimulates the release of the pro-inflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta from glial cells which consequently induces an impairment in neuronal cell function. The food supplement Aquamin is a natural, multi-mineral derived from the red algae Lithothamnion corallioides, rich in calcium, magnesium and 72 other trace minerals. The aim of this study was to evaluate the anti-inflammatory potential of Aquamin in lipopolysaccharide-stimulated, glial-enriched primary cultures of rat cortex. We report that Aquamin prevented lipopolysaccharide-induced secretion of tumor necrosis factor-alpha and interleukin-1beta from cortical glia. These data suggest that nutritional supplements such as Aquamin may play an important role in impeding the detrimental effects of excessive inflammation in the brain.

Mots clés: Life Sciences

Sinead Ryan, Denise O'Gorman, Yvonne Nolan. Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures.. Phytotherapy Research, 2010, ⟨10.1002/ptr.3309⟩. ⟨hal-00599843⟩