Prevalence of Low-Risk and High-Risk types of Human Papillomavirus and other risk factors for HPV infection in Germany Within Different Age Groups in Women up to 30 Years of Age: An Epidemiological Observational Study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Medical Virology Année : 2010

Prevalence of Low-Risk and High-Risk types of Human Papillomavirus and other risk factors for HPV infection in Germany Within Different Age Groups in Women up to 30 Years of Age: An Epidemiological Observational Study

Sonja Eberle
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Angelika Iftner
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  • PersonId : 903157
Barbara Holz
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  • PersonId : 903158
Norbert Banik
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  • PersonId : 903159
Wim Quint
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  • PersonId : 903160
Anja-Natascha Straube
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Résumé

HPV infection is frequent in young women and persistent infection may lead to cervical cancer. Therefore, vaccination against HPV is recommended for young women in the age group from 12-17 years in Germany. However, epidemiological data on the prevalence of HPV types and risk factors for infection for younger women in Germany is scarce. To address this, an observational study was performed in Germany including 1,692 women aged 10-30 years. After a routine Pap smear, cervical swabs were tested for high-risk and low risk HPV, respectively, using the Hybrid Capture 2 test, and genotyped using the PCR-based tests SPF10/LiPA25 and PapilloCheck. In addition, the women were interviewed regarding their medical history and lifestyle factors. 377 (22.28%) women had positive HC2 results. The proportion of HPV positive women was highest in the 20-22 age group with 28.3%. Predominant HPV types were HPV 16,42,51 and HPV 16,51,31 as defined by PapilloCheck and SPF10/LiPA25, respectively. 95.8% of women did not show signs of any cervical lesion. Adjusted analysis identified number of sexual partners (OR:1.105; 95% CI:[1.069-1.142]), smoking (OR:1.508;[1.155-1.968]) and vaccination against HPV (OR:0.589;[0.398-0.872]) rather than increasing age as risk associated with HPV infection. Comparison of the genotyping assays showed that they correspond well regarding the high-risk HPV types but less well for low-risk HPV types. This epidemiological study shows that high-risk HPV infection is common in young women in Germany. According to our data, vaccination of young women could have a potential impact on the prevention of HPV infection and cervical disease.

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Dates et versions

hal-00599780 , version 1 (11-06-2011)

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Thomas Iftner, Sonja Eberle, Angelika Iftner, Barbara Holz, Norbert Banik, et al.. Prevalence of Low-Risk and High-Risk types of Human Papillomavirus and other risk factors for HPV infection in Germany Within Different Age Groups in Women up to 30 Years of Age: An Epidemiological Observational Study. Journal of Medical Virology, 2010, 82 (11), pp.1928. ⟨10.1002/jmv.21910⟩. ⟨hal-00599780⟩

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