Do gender, age or life style factors affect responses to anti-muscarinic treatment in overactive bladder patients?

Tim Schneider (1) , Daniela Marschall-Kehrel (2) , Jens Ulrich Hanisch (3) , Martin C Michel (4)

1 Praxisklinik Urologie Rhein-Ruhr
2 Urological Practice
3 Dept. Non-Interventional Studies
4 Dept. Pharmacology & Pharmacotherapy

Aims: Gender, age, obesity, smoking, and alcohol or caffeine intake have been shown or proposed to be risk factors for the prevalence and/or severity of the overactive bladder symptom complex (OAB) or related parameters. We have explored whether any of these factors affects the therapeutic response to a muscarinic receptor antagonist during routine clinical use. Methods: Data were analyzed from 3766 OAB patients (77.1% female, age 62.6 ± 12.8 years) participating in an observational, open-label post-marketing surveillance study of the safety and efficacy of darifenacin. Multiple logistic regression models were applied to explore the effect of potential OAB risk factors on the darifenacin treatment-associated improvement of OAB symptoms, patient's subjective rating of bladder problems, and global efficacy and tolerability. Results: Age and (less consistently) gender were statistically significantly correlated with efficacy parameters, but the extent of their impact was judged to be too small to be clinically relevant. Except for a very small effect of body mass index on urgency episode improvement, none of the life style-associated factors had significant effects on the efficacy of darifenacin. Except for a very small age effect, none of the potential risk factors had significant effects on global tolerability. Discussion and conclusions: We conclude that the efficacy and tolerability of a muscarinic receptor antagonist such as darifenacin is largely independent of potential OAB risk factors such as gender, age, obesity, smoking and alcohol or caffeine intake.

Mots clés: Medicine

Tim Schneider, Daniela Marschall-Kehrel, Jens Ulrich Hanisch, Martin C Michel. Do gender, age or life style factors affect responses to anti-muscarinic treatment in overactive bladder patients?. International Journal of Clinical Practice, 2010, 64 (9), pp.1287. ⟨10.1111/j.1742-1241.2010.02442.x⟩. ⟨hal-00599539⟩