Adalimumab induction and maintenance therapy for ulcerative colitis patients previously treated with Infliximab.

Carlos Taxonera (1) , Jesús Estelles (2) , Ignacio Fernandez-Blanco (3) , Olga Merino (4) , Ignacio Marin-Jimenez (5) , Manuel Barreiro-de Acosta (6) , Cristina Saro (7) , Valle García-Sánchez (8) , Elena Gento (9) , Guillermo Bastida (10) , Javier Pérez-Gisbert (11) , Isabel Vera (12) , Pilar Martinez-Montiel (13) , Sara Garcia-Moran (9) , María Chaparro (14) , Juan Luis Mendoza (15)

1 Gastroenterology, IBD Unit
2 Aparato Digestivo
3 Hospital La Paz
4 Hopital de Cruces
5 Gastroenterology
6 Gastroenterology
7 Hospital de Cabueñes
8 Digestive Department
9 Hospital General Yagüe
10 Gastroenterology
11 Gastroenterology and Hepatology
12 Gastroenterology
13 Hospital 12 de Octubre
14 Gastroenterology and Hepatology
15 Digestive

Background: The long term efficacy of adalimumab in ulcerative colitis (UC) patients is not well known. Aim: To evaluate the short- and long-term outcomes of adalimumab in UC patients previously treated with infliximab. Methods: Patients with active UC were treated with adalimumab after failure of other therapies including infliximab. Short-term clinical response and remission were assessed at weeks 4 and 12. The proportion of patients who continued on adalimumab and the proportion of patients who remained colectomy-free were assessed over the long term. Results: Clinical response at weeks 4 and 12 was achieved in 16 (53.3%) and 18 (60%) patients, respectively, and clinical remission was obtained in 3 (10%) and 8 (26.7%) patients, respectively. After a mean 48 weeks follow-up, 15 patients (50%) continued on adalimumab. Six patients (20%) required colectomy. All patients who achieved clinical response at week 12 were colectomy-free at long term. Conclusions: Adalimumab was well tolerated and induced durable clinical response in many patients with otherwise medically refractory UC. Patients achieving clinical response at week 12 avoided colectomy over the long term.

Mots clés: Medicine

Carlos Taxonera, Jesús Estelles, Ignacio Fernandez-Blanco, Olga Merino, Ignacio Marin-Jimenez, et al.. Adalimumab induction and maintenance therapy for ulcerative colitis patients previously treated with Infliximab.. Alimentary Pharmacology and Therapeutics, 2010, 33 (3), pp.340. ⟨10.1111/j.1365-2036.2010.04531.x⟩. ⟨hal-00599507⟩