EFFECT OF ITOPRIDE ON ESOPHAGEAL MOTILITY AND LOWER ESOPHAGEAL SPHINCTER FUNCTION IN MAN

Emidio Scarpellini (1) , Rita Vos (1, 2) , Kathleen Blondeau (1, 3) , Veerle Boecxstaens (1) , Ricard Farre (1) , Antonio Gasbarrini (4) , Jan Tack (5)

1 Center for Gastroenterological Research
2 Gastroenterology, Center for Gastroenterological Research
3 Lab G-I Physiopathology
4 Internal Medicine
5 Center for Gastroenterological Research

Introduction: Itopride is a new prokinetic agent which combines antidopaminergic and cholinesterase inhibitory actions. Previous studies suggested that itopride improves heartburn in functional dyspepsia, and decreases esophageal acid exposure in GERD. It is unclear whether this effect is due to effects of itopride on the LES. Aims: To study the effects of itopride on fasting and postprandial LES function in healthy subjects. Materials and methods: twelve healthy volunteers (5 males; 32.6±2.0 years) underwent three esophageal sleeve manometry studies after 3 days premedication with itopride 50 mg, itopride 100mg or placebo t.i.d. Drug was administered after 30 minutes and a standardized meal was administered after 90 minutes, with measurements continuing to 120 minutes postprandially. Throughout the study, 10 wet swallows were administered at 30-minute intervals, and gastrointestinal symptoms were scored on 100 mm visual analogue scales (VAS) at 15-minute intervals. Results: LES resting pressures, swallow-induced relaxations and the amplitude or duration of peristaltic contractions were not altered by both doses of itopride, at all time points. Itopride pretreatment inhibited the meal-induced rise of transient LES relaxations (TLESRs). Conclusions: Itopride inhibits TLESRs without significantly affecting esophageal peristaltic function or LES pressure. These observations support further studies with itopride in GERD.

Mots clés: Medicine

Emidio Scarpellini, Rita Vos, Kathleen Blondeau, Veerle Boecxstaens, Ricard Farre, et al.. EFFECT OF ITOPRIDE ON ESOPHAGEAL MOTILITY AND LOWER ESOPHAGEAL SPHINCTER FUNCTION IN MAN. Alimentary Pharmacology and Therapeutics, 2010, 33 (1), pp.99. ⟨10.1111/j.1365-2036.2010.04487.x⟩. ⟨hal-00599484⟩