Liquid Chromatography on chip

Karine Faure (1)

1 SA - Sciences Analytiques

Liquid chromatography is one of the most powerful separation techniques as illustrated by its leading role in analytical sciences through both academic and industrial communities. Its implementation in microsystems appears to be crucial in the development of µTAS. If electrophoretic techniques have been widely used in miniaturized devices, liquid chromatography has faced multiple challenges in the downsizing process. During the past five years significant breakthroughs have been achieved in this research area, in both conception and use of liquid chromatography on chip. This review emphasizes on the development of novel stationary phases and their implementation in microchannels. Recent instrumental advances are also presented, highlighting the various driving forces (pressure, electrical field) that have been selected and their respective ranges of applications.

Mots clés: Life Sciences

Karine Faure. Liquid Chromatography on chip. Electrophoresis, 2010, 31 (15), pp.2499. ⟨10.1002/elps.201000051⟩. ⟨hal-00599462⟩