Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Jan Magdalan , Alina Ostrowska , Aleksandra Piotrowska , Agnieszka Gomułkiewicz , Marzena Podhorska-Okołów , Dariusz Patrzałek , Adam Szeląg , Piotr Dzięgiel

Fatalities due to mushroom poisonings are increasing worldwide, with high mortality rate resulting from ingestion of amanitin-producing species. Intoxications caused by amanitin-containing mushrooms represent an unresolved problem in clinical toxicology since no specific and fully efficient antidote is available. The objective of this study was a comparative evaluation of benzylpenicillin (BPCN), acetylcysteine (ACC) and silibinin (SIL) as an antidotes in human hepatocytes intoxicated with α-amanitin (α-AMA).

Mots clés: A- amanitin; Benzylpenicillin; Acetylcysteine; Silibinin; Amanita phalloides; Intoxication; Human hepatocytes

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, Marzena Podhorska-Okołów, et al.. Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin. Experimental and Toxicologic Pathology, 2010, 62 (4), pp.367. ⟨10.1016/j.etp.2009.05.003⟩. ⟨hal-00598190⟩