Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biochemical Pharmacology Année : 2010

Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways.

Résumé

Rimonabant (SR141716), a cannabinoid CB1 receptor antagonist known for anti-obesity activity, has more recently been shown to inhibit tumor cell growth. Here we demonstrated the anti-tumor potential of SR141716 in leukemia-derived cell lines and its low toxicity in normal cells (PBMC).

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hal-00596263 , version 1 (27-05-2011)

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Dario Gallotta, Patrizia Nigro, Roberta Cotugno, Patrizia Gazzerro, Maurizio Bifulco, et al.. Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways.. Biochemical Pharmacology, 2010, 80 (3), pp.370. ⟨10.1016/j.bcp.2010.04.023⟩. ⟨hal-00596263⟩

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