CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP

Mika Harju (1) , Leena Kurvinen (2) , Jukka Saari (2) , Eija Vesti (3)

1 Helsinki University Eye Hospital, Helsinki, Finland
2 Helsinki University Eye Hospital
3 Helsinki University Eye Hospital; Turku University Hospital, Turku, Finland

Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no defects on red-free nerve fibre layer photographs, and intraocular pressure (IOP) <22 mmHg. During the follow-up, no eye developed glaucoma; VFs remained normal, and no longitudinal changes appeared in nerve fibre layers assessed from red-free photographs or ONHs assessed from stereophotographs. The median baseline and follow-up IOPs were comparable (15 mmHg; range 10-20 mmHg, and 16 mmHg; 10-22mmHg, respectively; P=0.38). Images were re-evaluated with HRT III and ONHs graded as normal, borderline, or glaucomatous with the Moorfield's Regression Analysis (MRA). Results: Significant changes in HRT parameters indicating increased ONH cupping were detected in Cup Area (P=0.013), Cup-to Disc Area ratio (P=0.015), Rim Area (P=0.015), Mean Cup Depth (P=0.006), and Cup Shape Measure (P<0.001). With the MRA classification, nine eyes (9/31, 29%) had a change to the worse in the global or any of the sector classifications. Conclusion: Age-dependent changes occur in ONH topography detectable with the HRT.

Mots clés: Optic Nerve; Imaging

Mika Harju, Leena Kurvinen, Jukka Saari, Eija Vesti. CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP. British Journal of Ophthalmology, 2010, 95 (6), pp.818. ⟨10.1136/bjo.2010.186213⟩. ⟨hal-00595936⟩