Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials

Tomasz Zaremba (1, 2) , Huw Thomas (1) , Michael Cole (1) , Elizabeth R. Plummer (1) , Nicola J. Curtin (1)

1 Northern Institute for Cancer Research
2 Department of Clinical Biochemistry

Mots clés: PARP-1; PARP-1 activity; PARP-1 expression; PARP inhibitors; Doxorubicin; Monozygotic twins

Tomasz Zaremba, Huw Thomas, Michael Cole, Elizabeth R. Plummer, Nicola J. Curtin. Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials. Cancer Chemotherapy and Pharmacology, 2010, 66 (4), pp.807-812. ⟨10.1007/s00280-010-1359-0⟩. ⟨hal-00594821⟩