A common origin of synaptic vesicles undergoing evoked and spontaneous fusion

Yunfeng Hua (1) , Raunak Sinha (1) , Magalie Martineau (1) , Martin Kahms (1) , Jurgen Klingauf (1)

1 Cellular Biophysics

There is an ongoing controversy on the identity of synaptic vesicles (SVs) undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested spontaneous release to be driven by a resting pool of SVs refractory to stimulation. Here we demonstrate cross-depletion of spontaneously or actively recycling SV pools upon stimulation using three different optical tracers and identify the recycling pool as major source of spontaneous release.

Mots clés: Synaptic Transmission

Yunfeng Hua, Raunak Sinha, Magalie Martineau, Martin Kahms, Jurgen Klingauf. A common origin of synaptic vesicles undergoing evoked and spontaneous fusion. Nature Neuroscience, 2010, ⟨10.1038/nn.2695⟩. ⟨hal-00594790⟩