Evaluation of azithromycin, trovafloxacin and grepafloxacin as prophylaxis against experimental murine infection

Helen S. Atkins (1) , Stephen Spencer (2) , Simon D. Brew (2) , Dominic C. Jenner (1) , Armine M. Sefton (3) , Alastair P. Macmillan (2) , Timothy J.G. Brooks (1) , Andrew J.H. Simpson (1)

1 Department of Biomedical Sciences
2 Department of Statutory and Exotic Bacterial Diseases
3 Centre for Infectious Disease

The prophylactic potential of the azalide azithromycin as well as the fluoroquinolones trovafloxacin and grepafloxacin was assessed for the control of infection with in an experimental mouse model, determined by reduction in splenic bacterial burden. Trovafloxacin showed limited protective efficacy when administered 2h following a low-dose challenge, whereas grepafloxacin was ineffective In comparison, azithromycin provided significant control of infection both following low- and high-dose challenges. Overall, the data confirm the potential utility of azithromycin in the prophylaxis of brucellosis and suggest that neither trovafloxacin nor grepafloxacin would likely be valuable for post-exposure prophylaxis of infection.

Mots clés: Macrolide; Fluoroquinolone; Mouse

Helen S. Atkins, Stephen Spencer, Simon D. Brew, Dominic C. Jenner, Armine M. Sefton, et al.. Evaluation of azithromycin, trovafloxacin and grepafloxacin as prophylaxis against experimental murine infection. International Journal of Antimicrobial Agents, 2010, 36 (1), pp.66. ⟨10.1016/j.ijantimicag.2009.10.003⟩. ⟨hal-00594501⟩