No association of polymorphisms in the cell polarity gene with breast cancer risk

Thomas Dünnebier (1) , Klaus Schlaefer (2) , Michael Gilbert (1) , Christian Baisch (3) , Christina Justenhoven (4, 5) , Hiltrud Brauch (4, 5) , Volker Harth (3, 6) , Anne Spickenheuer (6) , Sylvia Rabstein (6) , Beate Pesch (6) , Thomas Brüning (6) , Yon-Dschun Ko (3) , Ute Hamann (1)

1 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
2 Unit of Environmental Epidemiology
3 Department of Internal Medicine
4 Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology [Stuttgart]
5 Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen
6 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance

The human homolog of the () tumor suppressor gene encodes a protein that regulates apical-basolateral polarity in mammalian epithelia and controls cell proliferation. Due to the role of cell polarity proteins in human cancers, we investigated whether genetic variability in impacts breast carcinogenesis and tumor pathology. Five genetic variants were analyzed for an association with breast cancer risk and histopathological tumor parameters using a single nucleotide polymorphism (SNP) tagging approach. Genotyping of five tag SNPs was performed by TaqMan allelic discrimination and RFLP-based PCR using the GENICA population-based breast cancer case-control collection including 1,021 cases and 1,015 age-matched controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by ordinal logistic regression. None of the tag SNPs was associated with breast cancer risk or tumor characteristics. Our findings suggest that genetic variability in the polarity gene does not contribute to breast cancer development.

Mots clés: Polymorphisms; Epithelial cell polarity; Breast cancer risk

Thomas Dünnebier, Klaus Schlaefer, Michael Gilbert, Christian Baisch, Christina Justenhoven, et al.. No association of polymorphisms in the cell polarity gene with breast cancer risk. Breast Cancer Research and Treatment, 2010, 127 (1), pp.259-264. ⟨10.1007/s10549-010-1194-3⟩. ⟨hal-00594470⟩