%0 Journal Article
%T Investigation of Low-Energy Proton Effects on Aptamer Performance for Astrobiological Applications
%+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
%+ Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB)
%+ Observatoire aquitain des sciences de l'univers (OASU)
%+ Université Sciences et Technologies - Bordeaux 1 (UB)
%+ Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux (L3AB)
%+ Département de pharmacochimie moléculaire (DPM)
%+ Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG)
%A Baque, Mickaël
%A Le Postollec, A.
%A Ravelet, C.
%A Peyrin, E.
%A Coussot, G.
%A Desvignes, Isabelle
%A Incerti, S.
%A Moretto, P.
%A Dobrijevic, M.
%A Vandenabeele-Trambouze, O.
%< avec comité de lecture
%Z IBMM:11-021
%@ 1531-1074
%J Astrobiology
%I Mary Ann Liebert
%V 11
%P 207-211
%8 2011
%D 2011
%Z 2011AsBio..11..207B
%R 10.1089/AST.2010.0520
%K Aptamer
%K Biochip
%K Microarray
%K Cosmic radiation
%Z Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP]
%Z Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP]Journal articles
%X Biochips are promising instruments for the search for organic molecules in planetary environments. Nucleic acid aptamers are powerful affinity receptors known for their high affinity and specificity, and therefore are of great interest for space biochip development. A wide variety of aptamers have already been selected toward targets of astrobiological interest (from amino acids to microorganisms). We present a first study to test the resistance of these receptors to the constraints of the space environment. The emphasis is on the effect of cosmic rays on the molecular recognition properties of DNA aptamers. Experiments on beam-line facilities have been conducted with 2 MeV protons and fluences much higher than expected for a typical mission to Mars. Our results show that this irradiation process did not affect the performances of DNA aptamers as molecular recognition tools.
%G English
%L hal-00589210
%U https://hal.science/hal-00589210
%~ IN2P3
%~ INSU
%~ UGA
%~ CENBG
%~ CNRS
%~ UNIV-GRENOBLE1
%~ ENSC-MONTPELLIER
%~ L3AB
%~ IBMM
%~ INC-CNRS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ UM-2015-2021
%~ TEST2-HALCNRS