The association of and -related gastroduodenal diseases
Résumé
is associated with the development of ulceration and gastric cancer. Recently, a novel virulence factor, duodenal ulcer promoting gene A (), has been identified and found to associate with disease in some populations but not others. We investigated the relationship of genotypes and -related clinical outcomes by meta-analysis using previous reports of 2,358 patients from around the world. -positive genotypes was found in 48% and was associated with duodenal ulcer ( = 0.001, odds ratio [OR] = 1.4, confidence interval [CI] = 1.1-1.7). The prevalence of -positivity and its association with disease differed among the various regions around the world. In South America, the highest prevalence was recorded (Colombia and Brazil) and a significant relationship was found between -negative strains and both gastric ulcer (GU) and gastric cancer (GC) (for GU, = 0.001, OR = 0.2, CI = 0.1-0.4 and for GC, = 0.001, OR = 0.3, CI = 0.2-0.6). In China, a significant correlation between -positive strains and GU ( = 0.001, OR = 5.5, CI = 2.4-12.4) and GC ( = 0.009, OR = 2, Cl = 1.1-3.1) was found. To conclude, promotes duodenal ulceration in some populations and GU and GC in others. This is typical of other virulence factors, such as . Hence, it was concluded that the virulence factor, , is a true virulence factor.
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