A(H5N1) Virus Evolution in South East Asia

Ramona Alikiiteaga Gutiérrez (1) , Monica Jane Naughtin (1) , Srey Viseth Horm (1) , Sorn San (2) , Philippe Buchy (1)

1 Institut Pasteur du Cambodge
2 National Animal Health and Production Investigation Center

Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an ongoing public health and socio-economic challenge, particularly in South East Asia. H5N1 is now endemic in poultry in many countries, and represents a major pandemic threat. Here, we describe the evolution of H5N1 virus in South East Asia, the reassortment events leading to high genetic diversity in the region, and factors responsible for virus spread. The virus has evolved with genetic variations affecting virulence, drug-resistance, and adaptation to new host species. The constant surveillance of these changes is of primary importance in the global efforts of the scientific community.

Mots clés: avian influenza; H5N1 virus; evolution; South East Asia

Domaines: Virologie

Ramona Alikiiteaga Gutiérrez, Monica Jane Naughtin, Srey Viseth Horm, Sorn San, Philippe Buchy. A(H5N1) Virus Evolution in South East Asia. Viruses, 2009, 1, pp.335-361. ⟨10.3390/v1030335⟩. ⟨hal-00583197⟩