Chromosomal aberrations in thyroid follicular-cell neoplasia: in the search of novel oncogenes and tumour suppressor genes - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2010

Chromosomal aberrations in thyroid follicular-cell neoplasia: in the search of novel oncogenes and tumour suppressor genes

Horst Zitzelsberger
  • Fonction : Auteur correspondant
  • PersonId : 898031

Connectez-vous pour contacter l'auteur
Gerry Thomas
  • Fonction : Auteur
Kristian Unger
  • Fonction : Auteur

Résumé

Thyroid cancer derived from the follicular cell is characterised by specific gene alterations that are closely linked to the various pathological types comprising papillary, follicular and anaplastic thyroid cancer. However, the correlation between molecular biology and pathology is not absolute, since about 30% of cases do not harbour the typical gene alterations. This situation, coupled with the demonstration of genetic heterogeneity in thyroid cancer, is a strong motivation for the search of novel gene alterations. Chromosomal aberrations are a good starting point to initiate this search and therefore the current knowledge on chromosomal alterations in thyroid follicular-cell neoplasia is reviewed in this article. An overview on molecular cytogenetic approaches for this strategy is also provided. The identification of novel genetic markers in thyroid cancer will be further improved by integrative approaches combining data from genomic and expression analyses with clinical clinical data. This approach is powerful to identify genetic markers as well as new therapeutic targets in follicular-cell thyroid cancer.
Fichier principal
Vignette du fichier
PEER_stage2_10.1016%2Fj.mce.2009.11.014.pdf (610.06 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00582106 , version 1 (01-04-2011)

Identifiants

Citer

Horst Zitzelsberger, Gerry Thomas, Kristian Unger. Chromosomal aberrations in thyroid follicular-cell neoplasia: in the search of novel oncogenes and tumour suppressor genes. Molecular and Cellular Endocrinology, 2010, 321 (1), pp.57. ⟨10.1016/j.mce.2009.11.014⟩. ⟨hal-00582106⟩

Collections

PEER
102 Consultations
259 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More