Interferon gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical swine fever virus infection in domestic pigs

J. Tarradas , J.M. Argilaguet , R. Rosell , M. Nofrarías , E. Crisci , L. Córdoba , E. Pérez , I. Díaz , F. Rodríguez , M. Domingo , M. Montoya , L. Ganges

Classical swine fever is a highly contagious viral infection affecting domestic and wild pigs. For CSFV, immunization with plasmids expressing different versions of glycoprotein E2 has proven an effective way to induce protection. Previously, we have also shown that immunization with DNA vaccine expressing glycoprotein E2 (DNA-E2) induced specific T helper cell responses in the absence of neutralizing antibodies. However, the role of T-cell responses in protection against CSFV is largely unknown.

Mots clés: protection; Classical swine fever virus; DNA vaccines; interferon gamma; protection.

J. Tarradas, J.M. Argilaguet, R. Rosell, M. Nofrarías, E. Crisci, et al.. Interferon gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical swine fever virus infection in domestic pigs. Veterinary Microbiology, 2010, 142 (1-2), pp.51. ⟨10.1016/j.vetmic.2009.09.043⟩. ⟨hal-00578400⟩