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Article Dans Une Revue European Journal of Clinical Microbiology and Infectious Diseases Année : 2010

Evaluation of the Immunoquick+4 malaria rapid diagnostic test in a non-endemic setting

Résumé

The aim of this retrospective study was to evaluate the Immunoquick+4 (BioSynex, Strasbourg, France), a three-band malaria rapid diagnostic test (MRDT) targeting histidine-rich protein-2 (HRP-2) and pan -specific parasite lactate dehydrogenase, in a non-endemic reference setting. Stored whole-blood samples ( = 613) from international travellers suspected of malaria were used, with microscopy corrected by polymerase chain reaction (PCR) as the reference method. Samples infected by ( = 323), ( = 97), ( = 73) and ( = 25) were selected, as well as 95 malaria-negative samples. The overall sensitivities of the Immunoquick+4 for the diagnosis of , , and were 88.9, 75.3, 56.0 and 19.2%, respectively. Sensitivity was significantly related to parasite density for (93.6% versus 71.4% at parasite densities >100/µl and ≤100/µl, respectively) and (86.8% versus 48.3% at parasite densities >500/µl and ≤500/µl, respectively). The Immunoquick+4 showed good reproducibility and reliability for both test results and line intensities. The Immunoquick+4 performed well for the detection of and .

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Dates et versions

hal-00577008 , version 1 (16-03-2011)

Identifiants

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D. P. J. Dijk, P. Gillet, E. Vlieghe, L. Cnops, M. Esbroeck, et al.. Evaluation of the Immunoquick+4 malaria rapid diagnostic test in a non-endemic setting. European Journal of Clinical Microbiology and Infectious Diseases, 2010, 29 (5), pp.577-583. ⟨10.1007/s10096-010-0898-y⟩. ⟨hal-00577008⟩

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