INVESTIGATION OF THE POTENTIAL OF POLYMER THERAPEUTICS IN CORNEAL RE-EPITHELIALISATION
Résumé
We describe the first use of a bioresponsive polymer therapeutic agent in the promotion of corneal re-epithelialisation after injury in an ex vivo whole-eye organ culture model. A polymer-protein conjugate consisting of dextrin and recombinant human epidermal growth factor (rhEGF) was synthesized and applied as a single dose to a 2mm ex vivo corneal ulcer, in culture. Enhanced wound healing was observed in response to dextrin-rhEGF, when exposed to α-amylase, compared to controls. This highlights the potential for polymer therapeutics to provide a platform for bioresponsive drug/protein delivery in the field of ophthalmology.
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